MRGPRX1 (mrgx1_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX1
GENE
MRGPRX1 (MRGX1, SNSR3, SNSR4)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
P
|
T
|
I
|
S
|
T
|
L
|
D
|
T
|
10 |
E
|
L
|
T
|
P
|
I
|
N
|
G
|
T
|
E
|
E
|
20 |
TM1 | |||||||||
T
|
L
|
C
|
Y
|
K
|
Q
|
T
|
L
|
S
|
L
|
30 |
T
|
V
|
L
|
T
|
C
|
I
|
V
|
S
|
L
|
V
|
40 |
G
|
L
|
T
|
G
|
N
|
A
|
V
|
V
|
L
|
W
|
50 |
ICL1 | |||||||||
L
|
L
|
G
|
C
|
R
|
M
|
R
|
R
|
N
|
A
|
60 |
TM2 | |||||||||
F
|
S
|
I
|
Y
|
I
|
L
|
N
|
L
|
A
|
A
|
70 |
A
|
D
|
F
|
L
|
F
|
L
|
S
|
G
|
R
|
L
|
80 |
I
|
Y
|
S
|
L
|
L
|
S
|
F
|
I
|
S
|
I
|
90 |
ECL1 | TM3 | ||||||||
P
|
H
|
T
|
I
|
S
|
K
|
I
|
L
|
Y
|
P
|
100 |
V
|
M
|
M
|
F
|
S
|
Y
|
F
|
A
|
G
|
L
|
110 |
S
|
F
|
L
|
S
|
A
|
V
|
S
|
T
|
E
|
R
|
120 |
ICL2 | |||||||||
C
|
L
|
S
|
V
|
L
|
W
|
P
|
I
|
W
|
Y
|
130 |
TM4 | |||||||||
R
|
C
|
H
|
R
|
P
|
T
|
H
|
L
|
S
|
A
|
140 |
V
|
V
|
C
|
V
|
L
|
L
|
W
|
A
|
L
|
S
|
150 |
L
|
L
|
R
|
S
|
I
|
L
|
E
|
W
|
M
|
L
|
160 |
ECL2 | |||||||||
C
|
G
|
F
|
L
|
F
|
S
|
G
|
A
|
D
|
S
|
170 |
TM5 | |||||||||
A
|
W
|
C
|
Q
|
T
|
S
|
D
|
F
|
I
|
T
|
180 |
V
|
A
|
W
|
L
|
I
|
F
|
L
|
C
|
V
|
V
|
190 |
L
|
C
|
G
|
S
|
S
|
L
|
V
|
L
|
L
|
I
|
200 |
ICL3 | |||||||||
R
|
I
|
L
|
C
|
G
|
S
|
R
|
K
|
I
|
P
|
210 |
TM6 | |||||||||
L
|
T
|
R
|
L
|
Y
|
V
|
T
|
I
|
L
|
L
|
220 |
T
|
V
|
L
|
V
|
F
|
L
|
L
|
C
|
G
|
L
|
230 |
P
|
F
|
G
|
I
|
Q
|
F
|
F
|
L
|
F
|
L
|
240 |
ECL3 | |||||||||
W
|
I
|
H
|
V
|
D
|
R
|
E
|
V
|
L
|
F
|
250 |
TM7 | |||||||||
C
|
H
|
V
|
H
|
L
|
V
|
S
|
I
|
F
|
L
|
260 |
S
|
A
|
L
|
N
|
S
|
S
|
A
|
N
|
P
|
I
|
270 |
I
|
Y
|
F
|
F
|
V
|
G
|
S
|
F
|
R
|
Q
|
280 |
C-term | |||||||||
R
|
Q
|
N
|
R
|
Q
|
N
|
L
|
K
|
L
|
V
|
290 |
L
|
Q
|
R
|
A
|
L
|
Q
|
D
|
A
|
S
|
E
|
300 |
V
|
D
|
E
|
G
|
G
|
G
|
Q
|
L
|
P
|
E
|
310 |
E
|
I
|
L
|
E
|
L
|
S
|
G
|
S
|
R
|
L
|
320 |
E
|
Q
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
bovine adrenal medulla peptide 8-22
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page